Masato Hasegawa Selected Research

TDP-43 Proteinopathies

1/2022	Age-dependent formation of TMEM106B amyloid filaments in human brains.
10/2020	Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.
11/2019	The basis of clinicopathological heterogeneity in TDP-43 proteinopathy.
1/2017	Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.
1/2016	Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43.
11/2014	Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.
7/2013	Prion-like properties of pathological TDP-43 aggregates from diseased brains.
3/2012	Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.
1/2012	Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
1/2011	[A new dementia group caused by TDP-43 abnormality].

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Masato Hasegawa Research Topics

Disease

55	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 12/2022 - 12/2006
47	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 02/2002
46	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 12/2006
39	Alzheimer Disease (Alzheimer's Disease) 04/2022 - 08/2003
39	Parkinson Disease (Parkinson's Disease) 01/2022 - 05/2002
33	Tauopathies 11/2022 - 08/2003
31	Dementia (Dementias) 01/2022 - 05/2002
30	Synucleinopathies 01/2022 - 02/2002
25	Multiple System Atrophy 01/2022 - 05/2002
24	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 05/2003
18	Corticobasal Degeneration 01/2022 - 04/2004
15	TDP-43 Proteinopathies 01/2022 - 11/2008
14	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 04/2002
8	Pick Disease of the Brain (Pick's Disease) 01/2022 - 04/2004
7	Parkinsonian Disorders (Parkinsonism) 10/2022 - 04/2004
7	Proteostasis Deficiencies 06/2021 - 11/2012
6	Disease Progression 10/2020 - 02/2011
4	Sarcoma (Soft Tissue Sarcoma) 12/2022 - 01/2010
4	Atrophy 03/2018 - 02/2011
3	Lewy Body Disease (Lewy Body Dementia) 12/2010 - 08/2003
2	Amyloid Plaque 01/2022 - 02/2011
2	Nervous System Diseases (Neurological Disorders) 10/2021 - 07/2019
2	Gliosis 08/2021 - 01/2021
2	Cognitive Dysfunction 01/2020 - 03/2018
2	Chronic Traumatic Encephalopathy 01/2020 - 12/2019
2	Motor Neuron Disease (Primary Lateral Sclerosis) 03/2018 - 12/2006
2	Neoplasm Metastasis (Metastasis) 06/2012 - 11/2011
2	Neoplasms (Cancer) 06/2012 - 11/2011
2	Huntington Disease (Huntington's Disease) 09/2009 - 12/2008
1	Subacute Sclerosing Panencephalitis (SSPE) 11/2022
1	Amyloidosis 01/2022
1	Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 11/2021
1	Apraxias (Dyspraxia) 08/2021
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2020
1	Schizophrenia (Dementia Praecox) 12/2019
1	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2019
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2019
1	Hypothyroidism 01/2018
1	Starvation 01/2017
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2017
1	Akinetic Mutism (Coma Vigil) 06/2016

Drug/Important Bio-Agent (IBA)

49	Proteins (Proteins, Gene)FDA Link 12/2022 - 02/2002
43	SynucleinsIBA 01/2022 - 04/2008
38	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022 - 12/2006
29	UbiquitinIBA 12/2022 - 12/2002
22	PrionsIBA 01/2022 - 01/2012
21	alpha-SynucleinIBA 01/2020 - 02/2002
17	Amyloid (Amyloid Fibrils)IBA 04/2022 - 02/2009
17	tau Proteins (tau Protein)IBA 12/2021 - 03/2005
16	sarkosylIBA 01/2022 - 04/2002
11	Protein AggregatesIBA 12/2022 - 07/2011
11	Protein Isoforms (Isoforms)IBA 01/2022 - 04/2004
10	AntibodiesIBA 03/2016 - 12/2002
7	ProgranulinsIBA 02/2018 - 11/2008
7	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2014 - 11/2008
4	Peptides (Polypeptides)IBA 01/2018 - 12/2002
4	Biomarkers (Surrogate Marker)IBA 05/2014 - 11/2009
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 12/2022 - 01/2013
3	Peptide Hydrolases (Proteases)FDA Link 01/2019 - 11/2010
3	Prion ProteinsIBA 01/2019 - 02/2005
3	GranulinsIBA 02/2018 - 02/2015
3	DipeptidesIBA 08/2015 - 10/2013
3	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 01/2013 - 10/2007
2	plexinIBA 12/2021 - 01/2021
2	1,3- bis(bis(pyridin- 2- ylmethyl)amino)propan- 2- olIBA 12/2021 - 02/2016
2	IronIBA 08/2021 - 03/2018
2	Ataxin-2IBA 10/2020 - 03/2014
2	AsparagineIBA 10/2020 - 08/2013
2	Amyloid beta-PeptidesIBA 02/2018 - 02/2006
2	Phosphotransferases (Kinase)IBA 01/2018 - 01/2013
2	Detergents (Detergent)IBA 01/2018 - 05/2002
2	Profilins (Profilin)IBA 04/2016 - 01/2016
2	EpitopesIBA 08/2013 - 01/2012
2	Pharmaceutical PreparationsIBA 01/2012 - 07/2011
2	Methylene Blue (Methylthioninium Chloride)FDA Link 01/2012 - 07/2009
2	Valosin Containing ProteinIBA 01/2010 - 11/2008
2	Messenger RNA (mRNA)IBA 11/2004 - 04/2004
2	Endopeptidase K (Proteinase K)IBA 11/2002 - 05/2002
1	neurochondrinIBA 12/2022
1	Antiviral Agents (Antivirals)IBA 11/2022
1	Levodopa (L Dopa)FDA LinkGeneric 10/2022
1	Monomeric GTP-Binding ProteinsIBA 01/2022
1	Casein Kinases (Casein Kinase)IBA 01/2022
1	THK5351IBA 01/2022
1	Phospho-Specific AntibodiesIBA 12/2021
1	High-Temperature Requirement A Serine Peptidase 1IBA 11/2021
1	candesartanIBA 11/2021
1	Hexachlorobenzene (HCB)IBA 10/2021
1	VaccinesIBA 01/2020
1	Ferritins (Ferritin)IBA 03/2018
1	CalciumIBA 10/2016
1	Docosahexaenoic AcidsIBA 04/2016

Therapy/Procedure

9	Therapeutics 11/2022 - 03/2005
1	Ligation 01/2022
1	Immunotherapy 01/2020
1	Psychosurgery (Lobotomy) 12/2019
1	Gastrostomy 06/2016
1	Tracheotomy 06/2016
1	Artificial Respiration (Mechanical Ventilation) 04/2016
1	Tracheostomy 04/2016